Had an issue where whenever a user attempted to access their Out of Office section in OWA 2010 they received an the following error when saving it:
"Sorry! We're having trouble processing your request at the moment. Please try again in a few minutes."
In this particular instance, Exchange 2010 is running on a 2012 server
Eventually tracked the issue down to certain applications pools in IIS being assigned to .net v4 instead of v2
To check this out yourself, open IIS and go to "application pools"
Look in the list to see what version .NET Framework is set to - in particular look at the highlighted ones below.
"DefaultAppPool", "MSExchangeECPAppPool" and "MSExchangeOWACalendarAppPool"
When I initially looked at IIS, these were set to v4.0. I double clicked on the them and changed them back to v2.0 as below
"Sorry! We're having trouble processing your request at the moment. Please try again in a few minutes."
In this particular instance, Exchange 2010 is running on a 2012 server
Eventually tracked the issue down to certain applications pools in IIS being assigned to .net v4 instead of v2
To check this out yourself, open IIS and go to "application pools"
Look in the list to see what version .NET Framework is set to - in particular look at the highlighted ones below.
"DefaultAppPool", "MSExchangeECPAppPool" and "MSExchangeOWACalendarAppPool"
When I initially looked at IIS, these were set to v4.0. I double clicked on the them and changed them back to v2.0 as below
This instantly resolved my issue!